Blar i forfatter "Hemmingsen, Lisa Myrseth"

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    • Advanced topical delivery systems for membrane-active antimicrobials. Exploring nature to improve antimicrobial wound therapy 

      Hemmingsen, Lisa Myrseth (Doctoral thesis; Doktorgradsavhandling, 2022-11-11)
      Currently, approximately 2% of the general population will experience at least one chronic wound throughout their lifetime. The numbers are expected to rise due to an aging population with a heightened disease burden. These wounds are major burdens for the patients; therefore, we need to find innovative approaches for bacterial eradication and improved wound treatment. We aimed to utilize nature’s ...

    • Chitosan Lecithin Nanoparticles with New Chemical Entity. Antimicrobial Evaluation 

      Hemmingsen, Lisa Myrseth (Master thesis; Mastergradsoppgave, 2015-05-13)
      Chronic wounds are often colonized with biofilm-producing bacteria, such as Staphylococcus epidermidis, and these wounds often have high degree of complexity and are often challenging to treat. There is a high resistance to the traditional antimicrobial treatments and that is why these infections sometimes are persistent. Photodynamic therapy (PDT) is proposed as a potential solution to the problems ...

    • Chitosan-based delivery system enhances antimicrobial activity of chlorhexidine 

      Hemmingsen, Lisa Myrseth; Panchai, Pimmat; Julin, Kjersti; Basnet, Purusotam; Nystad, Mona; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-29)
      Infected chronic skin wounds and other skin infections are increasingly putting pressure on the health care providers and patients. The pressure is especially concerning due to the rise of antimicrobial resistance and biofilm-producing bacteria that further impair treatment success. Therefore, innovative strategies for wound healing and bacterial eradication are urgently needed; utilization ...

    • Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control 

      Hemmingsen, Lisa Myrseth; Julin, Kjersti; Ahsan, Luqman; Basnet, Purusotam; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-12)
      Burns and other skin injuries are growing concerns as well as challenges in an era of antimicrobial resistance. Novel treatment options to improve the prevention and eradication of infectious skin biofilm-producing pathogens, while enhancing wound healing, are urgently needed for the timely treatment of infection-prone injuries. Treatment of acute skin injuries requires tailoring of formulation to ...

    • The Expanded Role of Chitosan in Localized Antimicrobial Therapy 

      Hemmingsen, Lisa Myrseth; Skalko-Basnet, Natasa; Jøraholmen, May Wenche (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-08)
      Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the opportunity to prolong the formulation residence time at mucosal sites; its wound healing properties open ...

    • Lecithin and Chitosan as Building Blocks in Anti-Candida Clotrimazole Nanoparticles 

      Hemmingsen, Lisa Myrseth; Panzacchi, Virginia; Kangu, Lloyd Mbugua; Giordani, Barbara; Luppi, Barbara; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-25)
      The main focus when considering treatment of non-healing and infected wounds is tied to the microbial, particularly bacterial, burden within the wound bed. However, as fungal contributions in these microbial communities become more recognized, the focus needs to be broadened, and the remaining participants in the complex wound microbiome need to be addressed in the development of new treatment ...

    • Liposomes-in-chitosan hydrogel boosts potential of chlorhexidine in biofilm eradication in vitro 

      Hemmingsen, Lisa Myrseth; Giordani, Barbara; Pettersen, Ann Kristin; Vitali, Beatrice; Basnet, Purusotam; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-16)
      Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity of liposomally-associated membrane active antimicrobials (MAA) and could potentially improve bacterial and biofilm eradication. Therefore, liposomes (∼300 nm) bearing chlorhexidine ...

    • Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide 

      Hemmingsen, Lisa Myrseth; Giordani, Barbara; Paulsen, Marianne Hagensen; Vanic, Zeljka; Flaten, Gøril Eide; Vitali, Beatrice; Basnet, Purusotam; Bayer, Annette; Strøm, Morten B.; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-13)
      The eradication of bacteria embedded in biofilms is among the most challenging obstacles in the management of chronic wounds. These biofilms are found in most chronic wounds; moreover, the biofilm-embedded bacteria are considerably less susceptible to conventional antimicrobial treatment than the planktonic bacteria. Antimicrobial peptides and their mimics are considered attractive candidates in the ...